Safer Medicines Trust is delighted to announce the appointment of Professor Barbara Pierscionek, PhD, MBA, LLM as our Scientific Director and Professor Chris Foster, MD, PhD, DSC, FRCPath as our Medical Director. They are both distinguished experts in human-focused biomedical research, who will lead the charity towards our goal of improving the safety of medicines and the future of biomedical research, by accelerating the paradigm shift from animal-based to human-relevant models.
Professor Pierscionek is Associate Dean of Research and Enterprise at Kingston University's Faculty of Science, Engineering and Computing. She qualified with clinical and scientific degrees (PhD in protein chemistry and optics) from the University of Melbourne and obtained an MBA and legal qualifications in the UK including the theoretical degree required for practice as a solicitor in England and Wales as well as a Masters degree in Law (LLM). Her scientific expertise is in the area of eye and vision research. She is a pioneer of multidisciplinary approaches leading to new insights into the vision and the ageing eye that have potential to improve outcomes for cataract patients in the design of new intraocular implants. She also works on the ethico-legal aspects of medical and biomedical research.
Professor Foster is the Medical Director of HCA Healthcare Laboratories, London, and Emeritus Professor of Pathology at the University of Liverpool. He is a leading specialist in the pathology of human cancers, particularly of the prostate, bladder and breast. Professor Foster received his BSc in Biochemistry at University College London and qualified in Medicine at the Westminster Medical School. He received his PhD from the Institute of Cancer Research and his MD at the Children’s Hospital of Philadelphia and the National Institutes of Health, Washington DC. In 2002, Professor Foster was awarded a DSc for his contribution to understanding “The Cellular and Molecular Biology of the Metastatic Process”.
Both professors have been Scientific Advisers to Safer Medicines Trust for several years and we are delighted that they are now taking on these leading roles. We welcome them both very warmly and look forward to them helping to lead the transition from animal models to human-relevant models.
Our article, written with Center for Responsible Science and published in ATLA, identifies some of the reasons for the glacial uptake of new, improved methods of safety assessment, and suggests ways forward, such as:
"...validation needs to become relative, rather than absolute. If a new test, or tests, can be shown to outperform what is currently required, that alone should suffice to ensure the continual and incremental replacement of underperforming tests with better ones, even if they are not yet perfect themselves. Unless this system of gradual improvement (which operates in almost every other sphere of endeavour) is adopted, the perfect will remain forever the enemy of the good."
"Perhaps the greatest barrier to the replacement of animal tests is the legal protection that they afford to pharmaceutical companies in litigation regarding adverse drug reactions. It is therefore imperative to increase awareness of the fallacy of such protection: unpredictive tests do not protect patients, and should no longer protect companies who continue to use them, when more-predictive methods not reliant on interspecies extrapolation are available."
Everyone understands that failing to update computer software leads to serious damage to computers. Yet we allow outdated protections for human health to go unfixed for decades. Is it any wonder that adverse drug reactions are now our fourth leading cause of death?
Editor in Chief of the Turkish Journal of Gastroenterology, Professor Hakan Sentürk, challenges other scientific journals to follow his lead and avoid publishing animal research, saying:
“Given the limitations of animal models, publishing animal studies would mislead the scientific community into futile research and give the general public false hope. This is unethical.”
He says: “Human-relevant approaches should be more aggressively developed and utilized instead. Fortunately, non-animal research methods like established clinical, computational and in vitro models abound, and new technologies like guts and other organs-on-chips are constantly being developed and validated.”