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Human-based Systems in Drug and Chemical Safety Testing - Toward Replacement, the 'Single R'

"With growing evidence of the shortcomings of laboratory animal testing to reliably predict human responsiveness to chemicals, questions are now being asked as to whether it is appropriate to use animals as human surrogates at all."

Dr Robert A. Coleman

ATLA - Alternatives To Laboratory Animals, Volume 42, Issue 6 - December 2014

ATLA is FRAME’s peer-reviewed scientific journal, published six times a year



A landmark study published on 28 July reveals how animal tests create a false sense of security, putting patients at risk.

The Observer published our letter, signed by many expert scientists, commenting on the study and urging governments to replace animal-testing requirements with an obligation to use the most reliably proved methods available. 

The Sunday Times also published our (different) letter, which began: "We hope the exciting technology mentioned in your article will become mainstream within three years as predicted. Meanwhile, other human-based technologies are already available that could be improving patient safety here and now. The impediment is not science but political will."



2014 Newsletter

2014 Newsletter

Our latest newsletter shows how close we are to reaching a tipping point, with science shifting inexorably towards human-focused research to deliver advances in medicine and more reliable safety tests.

Our mission is to accelerate this transition. Our comparative studies are designed to hasten this long-awaited shift. We have reached an exciting point, with partners ready to conduct our studies: the one thing we need now is funding, to get these studies underway.

Please help us if you can: the sooner we can demonstrate the superiority of human-based tests, the sooner they will be used routinely, in place of animal tests, to improve the safety of medicines.

Whatever you can afford to give will be extremely valuable and greatly appreciated - thank you!  



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