Safer Medicines Trust collaborating with FRAME
FRAME has recently published an analysis of the value of studies in dogs for predicting the safety of human medicines. The salient feature of this study is the use of appropriate statistical metrics, which have not previously been applied to such data. The results shine a new light on our reliance on dogs for this purpose, suggesting that they contribute little or nothing to ensuring our safety. Read the paper or watch the presentation by lead author Dr Jarrod Bailey.
We look forward to working with FRAME and OpenTox on a new study to assess the value of human in vitro approaches to predict the safety of medicines. Data will kindly be provided by the US Government ToxCast programme, part of the Tox21 initiative, and by the US National Center for Toxicological Research. The study will measure the ability of human in vitro tests to predict drug-induced liver injury (DILI) against the ability of animal tests to do so.
Safer Medicines Trust collaborating with OpenTox
We are thrilled to be working with the excellent EU-funded OpenTox project. OpenTox is working to support predictive toxicology, using a variety of human-relevant approaches, to meet the requirements of the REACH legislation and other global toxicological demands.
On 30 October, our US Science Director, Dr Katya Tsaioun, is speaking at the OpenTox USA InterAction meeting on Innovation in Predictive Toxicology. She will also present a poster outlining our groundbreaking proposal to compare the relative abilities of animal tests and human-based in vitro tests to predict the safety of medicines.